Multidisciplinary Management of Acromegaly and Its Deformities

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Patients with acromegaly have a 10-yr reduction in life expectancy compared with healthy subjects when left untreated. Surgical resection can provide durable biochemical remission of disease in nearly 100% of microadenomas as well as 61% of macroadenomas. In recalcitrant cases, a combination of medical therapy and/or radiosurgery can further improve rates of remission. Despite a multi-disciplinary approach, the skeletal deformities associated with acromegaly do not necessarily reverse by correction of abnormal growth hormone dynamics. In cases with severe craniofacial deformation as a result of chronic growth hormone exposure, surgical intervention to reverse coarse facial features and airway obstruction associated with this disease can improve the quality of life of a number of patients. We will describe here the current management strategies for acromegaly, including craniofacial and plastic surgery as well as future directions in the management of this complex disease.
Health Endocrinology
acromegaly, endocrinology, giants, gigantism, treatment

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